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Price erosion and supply reliability Despite the promise of the pipeline, incumbent molecules injectable semaglutide and tirzepatide will likely continue to lead a much-expanded GLP-1 global market in 2035

The phase 3 SURMOUNT programme assessed the safety and efficacy of tirzepatide as obesity treatment and the medication has now been approved (November 2023) for chronic weight management by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [46, 47]

Patients should inspect potential injection sites before each dose, avoiding areas with existing redness, bruising, scarring, or skin abnormalities

Fat mass reduction The body composition substudy measured total fat mass changes using dual-energy X-ray absorptiometry, the gold standard for distinguishing fat from lean tissue

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Commun 10, 4179 (2019)